朱晓岩

作者: 来源: 发布日期:2022-06-14 浏览次数:

一、基本信息朱晓岩.jpg

朱晓岩,女,籍贯内蒙古多伦,中共党员,博士,副教授,博士生导师。中国畜牧兽医学会动物解剖及组织胚胎学分会、中国神经科学学会、美国神经科学学会、美国动物科学学会和陕西省天然药物学会会员,陕西省药理学会生化与分子药理学专业委员会委员。国家自然科学基金委员会生命科学部通讯评议专家、教育部学位论文通讯评议专家。《Journal of Neuroinflammation》、《Journal of Neurochemistry》、《Frontiers in Pharmacology》等杂志审稿人。

二、教育及工作经历

(一)教育经历

2009年06月 毕业于内蒙古民族大学动物医学专业,获农学学士学位;

2012年12月 毕业于吉林大学动物医学学院临床兽医学专业,获农学硕士学位;

2017年01月 毕业于法国巴黎萨克雷大学医学院神经生物学专业,获博士学位;

(二)工作经历

2017年06月至2020年12月 动物医学院基础兽医系从事教学科研工作,讲师;

2021年01月至今 在西北农林科技大学动物医学院基础兽医系从事教学科研工作,副教授。

三、研究方向及讲授课程

研究方向:神经免疫内分泌方向,从事动物神经毒理与神经保护等相关研究工作。

讲授的本科生课程:《家畜解剖学及组织胚胎学》和《神经生物学》等课程;

讲授的研究生课程:《神经生物学专题》和《动物神经科学》等课程。

四、所获奖励及荣誉

2022年 陕西高等学校科学技术研究优秀成果奖(4/5);

2021年 西北农林科技大学青年教师讲课比赛二等奖和课程思政单项奖;

2021年 动物医学院青年教师讲课比赛一等奖和优秀教学设计奖;

2021年 动物医学院优秀共产党员;

2020年和2021年 动物医学院师德师风优秀;

2019年和2021年 动物医学院优秀班主任

2019年 优秀学业导师;

2019届 本科毕业生校级优秀毕业论文指导教师;

2019年 指导的本科生荣获第四届全国大学生生命科学竞赛陕西省三等奖;

2019年 中国畜牧兽医学会动物解剖及组织胚胎学分会第一届青年科学家学术论坛(优秀报告)。

五、科研项目

陕西省引进国外博士专项:糖剥夺条件下β-羟丁酸对奶山羊神经元损伤的保护作用及其机制研究,主持人。

陕西省重点研发项目(一般项目-农业领域)(2021/01-2022/12):杜仲叶型饲料添加剂抗奶山羊热应激关键技术研究,(2021NY-021),主持人。

国家自然科学基金青年项目(2019/01-2021/12):β-羟丁酸在低糖诱导奶山羊神经细胞炎性损伤中的保护作用及其机制(31802154),主持人。

中国博士后科学基金特别资助(2019/01-2020/11):BHBA对糖剥夺诱导奶山羊神经细胞损伤的保护机制,主持人。

中国博士后基金面上项目(一等资助)(2017/12-2019/11):BHBA对低糖致妊娠毒血症奶山羊神经细胞损伤的保护作用(2018M631210),主持人。

陕西省重点研发计划项目(2019/11-2022/11):元宝枫叶型畜禽饲料添加剂综合开发和利用(2019ZDXM3-02),子课题主持人。

陕西省技术创新引导专项(2020/01-2022/12):元宝枫油和神经酸营养和药用价值研究及相关产品开发,子课题主持人。

西北农林科技大学博士科研启动基金(2017/09-2020/08):P4调控热应激奶山羊PRL合成的机制研究,主持人。

陕西省自然科学基金(面上)(2018/01-2019/12):热应激条件下孕酮调控奶山羊催乳素分泌的影响研究,主持人。

六、代表性学术成果

(一)发表论文

Penghao Sun#, Mengli Wang#, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu*, XuejunChai*, Shanting Zhao*. Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism. Theranostics. 2022; 12(8): 3637-3655. (通讯作者)

Yuhuan Xue†, Xiaoyan Zhu†, Wenyong Yan, Zhihan Zhang, Enhui Cui, Yongji Wu, Cixia Li, Jiarong Pan, Qijiang Yan, Xuejun Chai* and Shanting Zhao*. Dietary supplementation with Acer truncatum oil promotes remyelination in a mouse model of multiple sclerosis. Frontiers in Neuroscience. 2022 May 02. doi: 10.3389/fnins.2022.860280. (共同一作)

Jian Huang, Xuejun Chai, Yongji Wu, Yan Hou, Cixia Li, Yuhuan Xue, Jiarong Pan, Yongkang Zhao, Aimin Su, Xiaoyan Zhu*, Shanting Zhao*. β-Hydroxybutyric acid attenuates heat stress-induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF-κB pathways in the hippocampus. FASEB J. 2022 Apr;36(4):e22264. doi: 10.1096.202101469RR. (通讯作者)

Cixia Li#, Xuejun Chai#, Jiarong Pan, Jian Huang, Yongji Wu, Yuhuan Xue, Wentai Zhou, Jiping Yang, Xiaoyan Zhu*, Shanting Zhao*. β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. Journal of Molecular Neuroscience. 2022 May;72(5):923-938. (通讯作者)

Xiaoyan Zhu*, Jian Huang, Yongji Wu, Shanting Zhao, Xuejun Chai*. Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits. Cell Mol Neurobiol. 2021 Nov 12. doi: 10.1007/s10571-021-01165-5.

Xiaoyan Zhu*, Yongji Wu, Jiarong Pan, Cixia Li, Jian Huang, Enhui Cui, Ziluo Chen, Wentai Zhou, Xuejun Chai*, Shanting Zhao*. Neuroinflammation induction and alteration of hippocampal neurogenesis in mice following developmental exposure to gossypol. Int J Neuropsychopharmacol. 2021, 24(5): 419–433.

Magalie Fréchou2, Xiaoyan Zhu2, Narender Kumarc, Regine Sitruk-Ware, Michael Schumacher, Claudia Mattern, Rachida Guennoun*. Sex differences in the cerebroprotection by Nestorone intranasal delivery following stroke in mice. Neuropharmacology. 2021 Oct 15;198:108760. doi: 10.1016/j.neuropharm.2021.108760. (共同一作)

Xiaoyan Zhu*, Yongji Wu, Cixia Li, Wenyong Yan, Jiarong Pan, Shuzhong Wang, Shanting Zhao*. Prenatal exposure to gossypol impairs corticogenesis of mouse. Frontiers in Neuroscience, 2020,14:318. doi: 10.3389/fnins.2020.00318.

Shuzhong Wang, Xuzhao Li, Qianru Zhang, Xuejun Chai, YiWang, Eckart Förster, Xiaoyan Zhu*, Shanting Zhao*. Nyap1 regulates multipolar-bipolar transition and morphology of migrating neurons by Fyn phosphorylation during corticogenesis. Cerebral Cortex, 2020, 30(3):929-941. (通讯作者)

Mengmeng Liu, Mingrui Xu, Mengli Wang, Shuzhong Wang, Kaikai Li, Xinran Cheng, Yongji Wu, Yi Wang, Xiaoyan Zhu*, Shanting Zhao*. Maternal exposure to swainsonine impaired the early postnatal development of mouse dentate gyrus of offspring. Neurochemistry International, 2019, 129:104511. (通讯作者)

Xiaoyan Zhu, Magalie Fréchou, Michael Schumacher, Rachida Guennoun*. Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology, 2019, 185:90-102.

Jinfeng Zhang1, Xiaoyan Zhu1, Yezi Kong, Yan Huang, Xukun Dang, Linshan Mei, Baoyu Zhao, Qing Lin*, Jianguo Wang*. Strontium stimulates alkaline phosphatase and bone morphogenetic protein-4 expression in rat chondrocytes cultured in vitro. Journal of Trace Elements in Medicine and Biology, 2019, 55:15-19. (共同一作)

Xiaoyan Zhu, Yezi Kong, Yan Huang, Baoyu Zhao, Jianguo Wang*. Influence of strontium on vascular endothelial growth factor and fibroblast growth factor 2 expression in rat chondrocytes cultured in vitro. Biological Trace Element Research, 2018, 190 (2): 466-471.

Mengmeng Liu, Guohong Li, Mengli Wang, Xinran Cheng, Yinxue Huang, Mingrui Xu, Kaikai Li, Jiong Chen, Xiaoyan Zhu*, Shanting Zhao*. Further studies about coactosin-like protein-1 affecting the migration of mouse neocortical neurons. Journal of Molecular Histology, 2018, 49(5):519-530. (通讯作者)

Xiaoyan Zhu, Magalie Fréchou, Philippe Liere, Shaodong Zhang, Antoine Pianos, Neïke Fernandez, Christian Denier, Claudia Mattern, Michael Schumacher*, and Rachida Guennoun*. A role of endogenous progesterone in stroke cerebroprotection revealed by the neural-specific deletion of its intracellular receptors. The Journal of Neuroscience, 2017, 37(45):10998-11020.

Xiaoyan Zhu, Jianguo Wang, Guanghong Xie, Haihua Feng, Xiaobing Li, Lei Liu, Xiaoxu Wang, Dongna Li, Zhaoxi Liu, Jian Qian, Zhe Wang, Guowen Liu*. Effect of copper on the expression of TGF-β in incubated chondrocytes of newborn pigs. Biological Trace Element Research, 2011, 143:1461-1469.

Jianguo Wang*, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu, Baoyu Zhao*. Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders. BMC Veterinary Research. 2018, 14(1):236. (共同一作)

Wenyan Yang, Jianguo Wang, Xiaoyan Zhu, Yunhang Gao, Zhaoxi Liu, Liang Zhang, Hui Chen, Xiaoxia Shi, Lianyu Yang, Guowen Liu*. High lever copper promote ghrelin gene expression in the fundic gland of growing pigs. Biological Trace Element Research. 2012;150:154-157. (共同一作)

Jianguo Wang, Xiaoyan Zhu, Chengzhen Chen, Xiaobing Li, Yan Gao, Peng Li, Yi Zhang, Miao Long, Zhe Wang*, Guowen Liu*. Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro. Molecular and Cellular Biochemistry, 2012, 362:87-91. (共同一作)

Jianguo Wang, Xiaoyan Zhu, Guanghong Xie, Yonghong Zhang, Zhaoxi Liu, Liang Zhang, Chenxu Zhao, Wentao Yang, Xiaoxia Shi, Zhe Wang*, Guowen Liu*. Effect of copper on the expression of IGF-1 from chondrocytes in newborn piglets in vitro. Biological Trace Element Research. 2012, 148:178-181. (共同一作)

Xue Yuan, Jianguo Wang, Xiaoyan Zhu, Zhigang Zhang, Yongxing Ai, Guoquan Sun, Zhe Wang*, Guowen Liu*. Effect of copper on levels of collagen and alkaline phosphatase activity from chondrocytes in newborn piglets in vitro. Biological Trace Element Research. 2011,144:597-605. (共同一作)

Jianguo Wang, Xiaoyan Zhu, Xiaobing Li, Wei Wang, Xiaoxu Wang, Lei Liu, Qinghua Deng, Ge Bai, Jianfa Wang, Haihua Feng, Zhe Wang*, Guowen Liu*. Effects of copper on proliferation and autocrine secretion of insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in chondrocytes from newborn pigs in vitro. Biological Trace Element Research, 2011, 144:588-596. (共同一作)

朱晓岩,王建国,杨连玉,秦贵信,张辉,王哲,刘国文*. 营养水平对杂交肉牛FABP3基因表达及IMF的影响。中国兽医学报,2011, 31(12):1781-1786.

朱晓岩,王建国,王晓旭,刘磊,邓清华,李东娜,王哲,刘国文*. 脂联素的最新研究进展。中国畜牧兽医,2010, 37(12):60-63.

(二)参编著作

元宝枫及神经酸研究现状报告,西北农林科技大学出版社,2020.06,参编

Schumacher, M., Zhu, X., Guennoun, R. Progesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous System. In: Pfaff, D.W and Joëls, M. (editors-in-chief), Hormones, Brain, and Behavior 3rd edition, Vol 3. Oxford: Academic Press; 2017. pp. 215–244. (导师一作)

(三)参加重要国际学术会议及报告情况

参会,2021/12,中国杨凌,陕西省畜牧兽医学会成立大会暨学术研讨会。

参会,2021/12,中国畜牧兽医学会动物解剖及组织胚胎学分会第九次会员代表大会暨第二十一次学术研讨会(线上会议)。

参会,2020/12,中国西安市,2020年首届神经生物物理青年科学论坛。

培训,2020/11,中国赤峰市,元宝枫母树林种子推广与示范项目培训班,培训内容“元宝枫产业现状和发展趋势以及元宝枫营养和药用价值研究”。

专题报告,2019/12,中国呼和浩特市,中国畜牧兽医学会动物解剖及组织胚胎学分会第一届青年科学家学术论坛,报告题目:Nyap1在小鼠大脑皮层发育中的作用及机制研究(优秀报告)。

专题报告,2019/12,中国贵州,2019全国杜仲产业发展高峰论坛,报告题目:杜仲发酵物在畜禽健康养殖中的应用与研究。

参会,2018/10,中国杨凌,全国元宝枫产业发展科技创新研讨会。

报告,2016/06,Paris, France, “Colloque de la Société Cerveau et Maladies Cérébrovasculaires (SCMC)”. 报告题目:Neural progesterone receptors: pivotal targets for enhancing the density of neurons, oligodendrocytes and their precursors and for reducing astrocytes and microglia density following stroke.

报告,2015/10, Paris, France, La journée de École Doctorale “Signalisations et Réseaux intégratifs en Biologie”, University Paris-Sud and University Paris-Saclay. 报告题目:Conditional inactivation of progesterone receptors gene in the nervous system: effects after ischemic stroke.

壁报,2015/05, Vienna, Austria, “24th European Stroke conference”. 壁报题目:Selective inactivation of progesterone receptor gene in the nervous system results in increased susceptibility to stroke.

参会,2015/05, Paris, France, “The neurovascular unit in health and disease”.

报告,2015/03, Paris, France, “Colloque de la Société Cerveau et Maladies Cérébrovasculaires (SCMC)”. 报告题目:CNS specific progesterone receptor invalidation leads to increased susceptibility to stroke.

参会,2014/10, Paris, France, Congrès des Jeunes Chercheurs en Biologie-Prix Réne Descartes.

参会,2013/12, Paris, France, Brain crosstalk in puberty and adolescence.

七、联系方式

通讯地址:陕西省杨凌示范区西农路22号西北农林科技大学动物医学院,712100

电子邮箱:xyzhu0922@nwsuaf.edu.cn; xyzhu0922@163.com