童德文

作者:   来源:  发布日期:2016-04-11 浏览次数:

  

  一、基本情况

  童德文,男,汉族,安徽省太湖县人,博士,三级教授,博士生导师,现任动医学院副院长,教育部新世纪优秀人才,陕西省重点科技创新团队“畜禽重大疫病新型疫苗研发创新团队”带头人,陕西省教学团队“基础兽医学教学团队” 带头人,陕西省精品资源共享课程“动物病理解剖学”负责人,西北农林科技大学基础兽医学学科带头人。

  二、研究方向

  动物病理学;细胞生理及病理

  三、个人简历

  1994年7月研究生毕业获农学硕士学位并留校从事动物病理学教研工作。

  1996年9月,考取西北农林科技大学临床兽医学专业博士研究生,2001年1月毕业获农学博士学位,同年12月晋升副教授,2002年遴选为硕士生导师。

  2005年被评为西北农林科技大学首批青年学术骨干,同年在新西兰Lincoln University研修。2007年遴选为博士生导师。

  近年来发表科研论文110余篇,获奖科研论文15篇。作为发明人申请了10项发明专利,其中5项已经授权,作为技术负责人和完成人鉴定和验收的科研成果3项。主持霍英东教育基金、国家自然科学基金、国际科学基金(IFS)、高等院校博士点基金和陕西省农业科技创新项目等项目。致力于宿主细胞和病原的相互作用研究和动物重大疫病新型疫苗研发。相关研究成果发表于Journal of Biological Chemistry, Veterinary Microbiology,Vaccine,Molecular and Cellular Endocrinology, PLoS One, Theriogenology, International Journal of Biological Science, Journal of General Virology, Virus Research , Journal of Virological Methods, Biochemical and Biophysical Research Communications等期刊,已培养毕业博士生7名、硕士生31名,在读全日制博士生10名、硕士生9名、博士后4名。

  四、代表性论著

  1.Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang,Lingling Chang,Xiaomin Zhao,XiaomaoLuo, Liang Zhang,Dewen Tong*, Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.

  2.Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong*, CD40 Ligand and GMCSF Coexpression Enhance the Immune Responses and Protective Efficacy of PCV2 Adenovirus Vaccine. Viral Immunology, 2016. 29(3): p. 148-158.

  3.Qian Du, Yong Huang, Tongtong Wang, Xiujuan Zhang, Yu Chen, Beibei Cui, Delong Li, Xiaomin Zhao, Wenlong Zhang, Lingling Chang, Dewen Tong*, Porcine circovirus type 2 activates PI3K/Akt and p38 MAPK pathways to promote interleukin-10 production in macrophages via Cap interaction of gC1qR. Oncotarget, 2016.

  4.Xiaomin Zhao, Hailing Xiang, XiaoyuanBai, NaijiaoFei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang, Dewen Tong*,Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virology Journal, 2016. 13(1): p. 26.

  5.Xiaomin Zhao, Xiangjun Song, XiaoyuanBai, NaijiaoFei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang,Dewen Tong*, miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1).Peerj, 2016. 4: p. e1635.

  6.Ruichao Huo, Lili Wang, Xiaoya Wang, Yong Zhao, Yi Wang, Xiaomin Zhao, Lingling Chang, Shanlu Liu, Dewen Tong,Hai Zhang*, Yong Huang*, Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice. Oncotarget, 2016.

  7.Yunpeng Fan, Xia Ma, Jing Zhang, Lin Ma, YuanyuanGao, Weimin Zhang, Xiao ping Song*, WeifengHou, Chao Guo, Dewen Tong*, Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydrate Polymers, 2015. 119: p. 219-227.

  8.Yunpeng Fan,Meimei Ren, WeifengHou,Chao Guo,Dewen Tong*, Lin Ma, Weimin Zhang, Mengmeng He, Xiaoping Song*, The activation of Epimedium polysaccharide-propolis flavone liposome onKupffer cells. Carbohydrate Polymers, 2015. 133: p. 613-623.

  9.Yong Huang, Na Xing, Zengguo Wang, Xiujuan Zhang, Xiaomin Zhao, Qian Du, Lingling Chang, Dewen Tong*,Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR Assay.PLoS One, 2015. 10(11): p. e0141545.

  10.Xiangjun Song, Xiaomin Zhao, Yong Huang, Hailing Xiang, Wenlong Zhang,Dewen Tong*,Transmissible Gastroenteritis Virus (TGEV) Infection Alters the Expression of Cellular MicroRNA Species That Affect Transcription of TGEV Gene 7. International Journal of Biological Sciences, 2015. 11(8): p. 913-922.

  11.Jiutao Wang, Lingzhen Song, Qi Zhang, Wei Zhang, Lei An, Yamei Zhang, Dewen Tong, Baoyu Zhao, Shulin Chen, Shanting Zhao*, Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory. Toxicology Letters, 2015. 232(1): p. 263-270.

  12.XingangXu, Honglei Zhang, Qi Zhang, Jie Dong, Yong Huang, Dewen Tong*,Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells.ActaVirologica, 2015. 59(3): p. 265-275.

  13.Hongling Zhang, Yong Huang, Qian Du, XiaomaoLuo, Liang Zhang, Xiaomin Zhao, Dewen Tong*,Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and Biophysical Research Communications, 2015. 456(2): p. 649-655.

  14.Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, XingangXu, Dewen Tong*,TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and Biophysical Research Communications, 2014. 445(2): p. 497-503.

  15.Yunpeng Fan, Xiaoping Song, YuanyuanGao, Ying Chen, Lin Ma, Weimin Zhang, WeifengHou, Chao Guo,Dewen Tong*, Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. International Journal of Pharmaceutics, 2014. 477(1-2): p. 421-430.

  16.Yong Huang, Feng Dong, Qian Du, Hongling Zhang, XiaomaoLuo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Tong*, Swainsonine Induces Apoptosis through Mitochondrial Pathway and Caspase Activation in Goat Trophoblasts. International Journal of Biological Sciences, 2014. 10(7): p. 789-797.

  17.Yong Huang, Xiujuan Zhang, Qian Du, Fengyu Wang, Xiaomin Zhao, WenlongZhang,DewenTong*, Preclinical Detection of Porcine Circovirus Type 2 Infection Using an Ultrasensitive Nanoparticle DNA Probe-Based PCR Assay.Plos One, 2014. 9(5): p. e97869.

  18.Wei Li, Yong Huang, Xiaomin Zhao, Wenlong Zhang, Feng Dong, Qian Du,Dewen Tong*, Swainsonine Induces Caprine Luteal Cells Apoptosis via Mitochondrial-Mediated Caspase-Dependent Pathway. Journal of Biochemical and Molecular Toxicology, 2014. 28(10): p. 456-464.

  19.Jun Zhang, Dan Xu, JiaNie, Jingsong Cao, YonggongZhai, Dewen Tong*, Yuguang Shi*, Monoacylglycerol Acyltransferase-2 Is a Tetrameric Enzyme That Selectively Heterodimerizes with Diacylglycerol Acyltransferase-1. Journal of Biological Chemistry, 2014. 289(15): p. 10909-10918.

  20.Li Ding, Yong Huang, Meiling Dai, Xiaomin Zhao, Qian Du, Feng Dong, Lili Wang, RuichaoHuo, Wenlong Zhang, XingangXu, Dewen Tong*, Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Research, 2013. 178(2): p. 241-251.

  21.Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang,Dewen Tong*, Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and Biophysical Research Communications, 2013. 442(1-2): p. 33-37.

  22.Feng Dong, Yong Huang, Wei Li, Xiaomin Zhao, Wenlong Zhang, Qian Du, Hongling Zhang, Xiangjun Song, Dewen Tong*,The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta, 2013. 34(12): p. 1243-1250.

  23.Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, XingangXu,Dewen Tong*,Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. Journal of General Virology, 2013. 94: p. 1807-1817.

  24.Yong Huang, Wei Li, Xiaomin Zhao, Li Ding, Gaoshui Yu, Feng Dong, Qian Du, XingangXu,Dewen Tong*,Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro.Theriogenology, 2013. 80(1): p. 41-49.

  25.Yong Huang, Meng Shao, XingangXu, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Wenlong Zhang, YahuiLyu,Dewen Tong*, Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Research, 2013. 175(1): p. 78-86.

  26.XingangXu, Honglei Zhang, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hungjen Liu*, Dewen Tong*, Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal, 2013. 10: p. 26.

  27.XingangXu, Honglei Zhang, Qi Zhang, Yong Huang, Jie Dong, Yabing Liang, Hungjen Liu*, Dewen Tong*, Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Veterinary Microbiology, 2013. 164(3-4): p. 212-221.

  28.Wenlong Zhang, Gaoshui Yu, Yong Huang, Dan Xu, JingjingRen, Liang Jiang, Changlong Wu, Dewen Tong*,Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro. Molecular and Cellular Endocrinology, 2013. 370(1-2): p. 20-31.

  29.Huiling Chen, Xinyu Cao*, Jingnan Zhang, Jingjing Zhang, Yongmei Ma*, Guangqin Shi, YucaiKe, Dewen Tong, Lei Jiang, Electrospunshape memory film with reversible fibrous structure. Journal of Materials Chemistry, 2012. 22(42): p. 22387-22391.

  30.Li Ding, XingangXu, Yong Huang, Zhaocai Li,Kuan Zhang, Guangda Chen, Gaoshui Yu,  Zhisheng Wang, Wei Li, Dewen Tong*, Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Veterinary Microbiology, 2012. 158(1-2): p. 12-22.

  31.Wei Li, XingangXu, Yong Huang, Zhaocai Li, Gaoshui Yu, Zhisheng Wang, Li Ding, Dewen Tong*,Establishment and evaluation of a stable steroidogeniccaprine luteal cell line.Theriogenology, 2012. 78(2): p. 263-272.

  32.Zhaocai Li, Yong Huang, Feng Dong, Wei Li, Li Ding, Gaoshui Yu, Dan Xu, Yuanyuan Yang, XingangXu, Dewen Tong*,Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. Journal of Biosciences, 2012. 37(6): p. 1005-1016.

  33.XingangXu, Guangda Chen, Yong Huang, Li Ding, Zhaocai Li, Chingdong Chang, Chiyoung Wang, Dewen Tong*, Hungjen Liu*, Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods, 2012. 183(1): p. 69-74.

  34.XingangXu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Li Ding, Wei Li, Hungyi Wu,Chingdong Chang, Longhuw Lee, Dewen Tong*,Hungjen Liu*, Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: Baculovirusvirions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods, 2012. 179(2): p. 359-366.

  35.Xingang Xu, Kuan Zhang, Yong Huang, Li Ding, Guangda Chen, Honglei Zhang, Dewen Tong*,Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virology Journal, 2012. 9: p. 202.

  36.XingangXu, Hongni Zhao, Qi Zhang, Li Ding, Zhaocai Li, Wei Li, Hungyi Wu,Kuopin Chuang, Dewen Tong*,Hungjen Liu*, Oral vaccination with attenuated Salmonella entericaserovarTyphimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology, 2012. 157(3-4): p. 294-303.

  37.Gaoshui Yu, Wenlong Zhang, Yong Huang, Li Ding, Wei Li, Zhaocai Li, Dan Xu, Feng Dong, Qian Du, Dewen Tong*,Expression and Distribution Pattern of Ghrelin in the Gastrointestinal Tract of Saanen Dairy Goat. Journal of Animal and Veterinary Advances, 2012. 11(24): p. 4585-4592.

  38.Zhaocai Li, XingangXu, Yong Huang, Li Ding, Zhisheng Wang, Gaoshui Yu, Dan Xu, Wei Li, Dewen Tong*, Swainsonine Activates Mitochondria-mediated Apoptotic Pathway in Human Lung Cancer A549 Cells and Retards the Growth of Lung Cancer Xenografts. International Journal of Biological Sciences, 2012. 8(3): p. 394-405.

  39.Zhisheng Wang, Xingang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu, Dewen Tong*,Immunogenicity of the envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus.ActaVirologica, 2011. 55(2): p. 139-146.

  40.Zhisheng Wang, Xinggang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu, Dan Xu, Dewen Tong*,Immunogenicity of envelope GP5 protein displayed on baculovirus and protective efficacy against virulent porcine reproductive and respiratory syndrome virus challenge in piglets. African Journal of Microbiology Research, 2011. 5(18): p. 2682-2691.

  41.Xingang Xu, Dewen Tong, Zhisheng Wang, Qi Zhang, Zhaocai Li, Kuan Zhang, Wei Li, Hungjen Liu*,BaculovirusVirions Displaying Infectious Bursal Disease Virus VP2 Protein Protect Chickens Against Infectious Bursal Disease Virus Infection. Avian Diseases, 2011. 55(2): p. 223-229.

  42.Xingang Xu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Hongni Zhao, Wei Li,Dewen Tong*,Hungjen Liu*,Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine, 2011. 29(4): p. 636-643.

  43.Zijiang Yang, Chiyoung Wang, Longhuw Lee, Kuopin Chuang, Yiyang Lien, Hsiensheng Yin,Dewen Tong, Xingang Xu, Hungjen Liu*, Development of ELISA kits for antibodies against avian reovirus using the sigma C and sigma B proteins expressed in the methyltropic yeast Pichiapastoris. Journal of Virological Methods, 2010. 163(2): p. 169-174.

  44.Jinyi Wang*, Li Ren, Li Li, Wenming Liu, Jing Zhou, Wenhao Yu,Dewen Tong,Shulin Chen,Microfluidics: A new cosset for neurobiology. Lab on a Chip, 2009. 9(5): p. 644-652.

  45.Jinyi Wang*, Li Ren, Xueqin Wang, Qiang Wang, Zongfang Wan, Li Li, Wenming Liu, Xuming Wang, Manlin Li, Dewen Tong,Ajing Liu, Bingbing Shang,Superparamagnetic microsphere-assisted fluoroimmunoassay for rapid assessment of acute myocardial infarction. Biosensors & Bioelectronics, 2009. 24(10): p. 3097-3102.

  46.Jinyi Wang*, Qiang Wang, Li Ren, Xueqin Wang, Zongfang Wan, Wenming Liu, Li Li, Huiying Zhao, Manlin Li,Dewen Tong, Juan Xu,Carboxylated magnetic microbead-assisted fluoroimmunoassay for early biomarkers of acute myocardial infarction. Colloids and Surfaces B-Biointerfaces, 2009. 72(1): p. 112-120.

  47.Xingang Xu,Dewen Tong,Mingtang Chiou, Yaoching Hsieh, Wenling Shih, Chingdong Chang, Minghuei Liao, Yanming Zhang, Hungjen Liu*,Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus. Journal of Virological Methods, 2009. 159(2): p. 259-264.

  48.Xueyi Yang, Nicanor I. Moldovan, Qingmei Zhao, ShengliMi, Zhenhui Zhou, Dan Chen, ZhiminGao, Dewen Tong,Zhongying Dou*, Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells. Molecular Vision, 2008. 14(127): p. 1064-1074.

  49.XingangXu, MingtangChiou, Yanming Zhang, Dewen Tong,Jianhe Hu, Miaotao Zhang, Hungjen Liu*, Baculovirus surface display of E-rns envelope glycoprotein of classical swine fever virus. Journal of Virological Methods, 2008. 153(2): p. 149-155.

  50.Dewen Tong*,Jinyi Wang*, Peihong Mu, Qiang Dong, Baoyu Zhao, Wenming Liu, Jun Zhao, Li Li, Tao Zhou, Analysis of several serum enzymes and blood urea nitrogen of swainsonine-HSA immunized goats. Animal Feed Science and Technology, 2008. 142(1-2): p. 74-88.

  51.Dewen Tong*, Peihong Mu, Qiang Dong, Baoyu Zhao, Wenming Liu, Jun Zhao, Li Li, Tao Zhou, Jinyi Wang*, Guodong Sui*,Immunological evaluation of SW-HSA conjugate on goats. Colloids and Surfaces B-Biointerfaces, 2007. 58(1): p. 61-67.

  五、科研项目

  近年来主持的科研项目:

  1. 国家自然科学基金

  2. 霍英东教育基金

  3. 国际科学基金

  4. 高等院校博士点基金

  5. 转基因生物新品种培育科技重大专项(子项目)

  6. 陕西重点科技攻关项目

  7. 动物重大疫病新型疫苗研发

  六、荣誉及奖项

  教育部新世纪优秀人才;三秦人才。

  七、社会兼职

  中国畜牧兽医学会动物病理学分会常务理事;中国畜牧兽医学会动物毒物学分会常务理事;《动物医学进展》杂志副主编;国家科技奖评审专家;国家自然科学基金评审专家等。

  八、联系方式

  电子邮箱:tdw8888@sina.com

  


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