王爱华

作者:   来源:  发布日期:2017-07-20 浏览次数:

  

一、基本信息

  王爱华,女,1966年9月出生,籍贯陕西合阳县,博士,教授,博士生导师。中国微生物学会兽医微生物学专业委员会委员,兽医微生物学专业委员会教学组委员,陕西省微生物学会理事 ,《动物医学进展》编委。

二、教育及研究经历

  1989年6月本科毕业于西北农业大学兽医系5年制兽医专业,获农学学士学位;2008年6月博士毕业于西北农林科技大学动物医学院临床兽医学专业,获农学博士学位。1989年7月至1992年6 月在天津市农工商总公司东海公司现代化养鸡厂从事兽医工作,助理兽医师兼兽医室主任;1992年7月至今于西北农林科技大学动物医学院预防兽医学系从事教学与科研工作,先后晋升为讲师、副教授、教授;2006年7月至2006年12月于加拿大圭尔夫大学细胞与分子生物学系研修。

三、研究方向及开设课程

  研究方向:分子病原学与免疫学、动物疫病防制。

  主要研究内容:病原微生物致病机制、病原与宿主互作、检测制剂及新型疫苗。

  开设课程:畜牧微生物学、动物微生物与免疫学、兽医微生物学

四、代表性学术成果

  [1]Wang X, Lin P, Li Y, Xiang C, Yin Y, Chen Z, Du Y, Zhou D, Jin Y, and Wang A*. Brucella suis Vaccine Strain 2 Induces Endoplasmic Reticulum Stress that Affects Intracellular Replication in Goat Trophoblast Cells In vitro.Front Cell Infect Microbiol. 2016, 6: 19. doi: 10.3389/fcimb.2016.00019.

  [2]Chen F, Wang N, Yang D, Wen X, Mahmoud T N, Zhou D, Tang K, Lin P, Wang A*, and Jin Y.. Herp depletion arrests the S phase of the cell cycle and increases estradiol synthesis in mouse granulosa cells.J Reprod Dev. 2016 Jan 15. [Epub ahead of print]

  [3]Chen F, Lin P, Wang N, Yang D, Wen X, Zhou D, Wang A*, and Jin Y. Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages. Toxicol In Vitro. 2016, 32: 115-122

  [4]Zhou J, Dai R, Lei L, Lin P, Lu X, Wang X, Tang K, Wang A, and Jin Y. Establishment and evaluation of a stable steroidogenic goat Leydig cell line. Anim Sci J. 2016, 87(4):492-502

  [5]Chen F L, Li Q, Zhang J Y, Lei L J, Zhang Z, Mahmoud T N, Wang X G, Lin P F, Jin Y P, and Wang A H*. Silencing effect of lentiviral vectors encod-ing shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages.Genet Mol Res.2015, 14(4): 17587-91758

  [6]Lin P, Chen F, Sun J, Zhou J, Wang X, Wang N, Li X, Zhang Z, Wang A*, and Jin Y. Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmic reticulum stress-dependent signalling pathway.Reprod Toxicol. 2015, 52: 71-77

  [7]Wang X, Lin P, Yin Y, Zhou J, Lei L, Zhou X, Jin Y, and Wang A. Brucella suis vaccine strain S2-infected immortalized caprine endometrial epithelial cell lines induce non-apoptotic ER-stress.Cell Stress Chaperones. 2015, 20(3): 399-409

  [8]Chen F, Li Q, Zhang Z, Lin P, Lei L, Wang A*, and Jin Y. Endoplasmic Reticulum Stress Cooperates in Zearalenone-Induced Cell Death of RAW 264.7 Macrophages.Int J Mol Sci.2015, 16(8): 19780-19795

  [9]Chen F, Lin P F, Li X, Sun J, Zhang Z, Du E, Wang A, and Jin Y P. Construction and expression of lentiviral vectors encoding recombinant mouse CREBZF in NIH 3T3 cells.Plasmid.2014, 76C: 24-31

  [10]Lin P, Jin Y, Lan X, Yang Y, Chen F, Wang N, Li X, Sun Y, and Wang A*. GRP78 expression and regulation in the mouse uterus during embryo implantation. J Mol Histol.2014, 45(3): 259-268

  [11]Lin P, Lan X, Chen F, Yang Y, Jin Y, Wang A*. Reference gene selection for real-time quantitative PCR analysis of the mouse uterus in the peri-implantation period. PLoS One. 2013, 8(4): e62462.

  [12]Lin P, Chen F, Wang N, Wang X, Li X, Zhou J, Jin Y, Wang A*. CREBZF expression and hormonal regulation in the mouse uterus. Reproductive Biology and Endocrinology, 2013;11(1):110. doi:10.1371/journal.pone.0062462

  [13]Lan X, Jin Y, Yang Y, Lin P, Hu L, Cui C, Li Q, Li X, Wang A*. Expression and localization of Luman RNA and protein during mouse implantation and decidualization. Theriogenology.  2013, 80(2):138-144.

  [14]Yang Y, Jin Y, Martyn AC, Lin P, Song Y, Chen F, Hu L, Cui C, Li X, Li Q, Lu R, Wang A* . Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice. Journal Reproduction and Development. 2013, 59(3): 245-251.

  [15]Yang Y, Jin Y, Lin P, Hu L, Cui C, Li X, Li Q, Wang A*.The expression and localization of LRF in the female reproductive tract of cycling mice throughout the estrous cycle. Journal of  Immunoassay and Immunochemistry. 2013, 34(4): 313-322.

  [16]Xuefeng Qi, Yanyan Qu, Zhichun Nan, Yaping Jin, Xianjun Zhao, Aihua Wang* Stromal-epithelial interactions modulate the effect of ovarian steroids on goat uterine epithelial cell interleukin-18 release. Domestic Animal Endocrinology, 2012, 42: 210-21.

  [17]Lin PF, Chen FL, Yang YZ, Song YJ, Li X, Lan XL, Jin YP, Wang. AH*.GRP78 expression and immunohistochemical localization in the female reproductive tract of mice. Theriogenology, 2012, 78: 1824-1829.

  [18] Xuefeng Qi, Yanyan Qu, Zhichun Nan, Yaping Jin, Xianjun Zhao, Aihua Wang*. Caprine endometrial stromal cells modulate the effects of steroid hormones on cytokine secretion by endometrial epithelial cells in vitro. Reproductive Biology, 2012, 12(3):309-315.

  [19]Hu L,Cui C, Song Y,Wang X,Jin Y, Wang A*, Zhang Y. An alternative method for cDNA cloning from surrogate eukaryotic cells transfected with the corresponding genomic DNA. Biotechnology Letters, 2012, 34: 1251-1255.

  [20]Yanyan Zhang, Aihua Wang*, Qingxia Wu, Hongxia Sheng, Yaping Jin. Establishment and characteristics of immortal goat endometrial epithelial cells and stromal cells with hTERT. Journal of animal and veterinary advances, 2010, 9(21): 2738-2747.

  [21] Lei Yang, Xiangguo Wang, Lanjie lei, Guangdong Zhang, Qin Xu, Jianpo Zhang, Chunnan Zhang, Jiao Yu, Pengfei Lin, Yaping Jin, Aihua Wang*. Construction of eukaryotic expression vector of main B. Melitensis S19 outer membrane proteins. Journal of Pure and Applied Microbiology, 2014, 8(1),

  [22]胡林勇, 陈华涛, 李倩, 徐晓彬, 王爱华, 靳亚平. 山羊β-乳球蛋白基因打靶载体的构建[J]. 中国农业科学, 2011, 44(11):2364-2370

  [23]《畜牧微生物学实验指导》王爱华编著.北京:中国农业出版社. ISBN 978-7-109-17194-72012.国家级动物科学实验教学示范中心系列资助教材

  [24]国家发明专利:一种法氏囊素的提取方法及其在疾病治疗和免疫中的应用,ZL200310105809. 第1发明人

五、科研项目

  1. Luman在布鲁氏菌调节非折叠蛋白反应和细胞凋亡抑制中的作用及其机制研究,国家自然科学基金(31672584),主持,直接经费58万元,2017.01-2020.12

  2. 奶山羊重大疫病防控关键技术研究与示范,陕西省科技厅(2016KTZDNY02-06),直接经费15万元,2017.01-2019.12

  3.羊布鲁菌病防控与预警关键技术研究,陕西省农业创新(2012NKC01-17),主持,10万元,2012-2014

  4.畜禽疫病检测诊断技术与疫苗研制,陕西省科技攻关(2009K01-19),主持,3万元,2009-2011

  5.内质网应激在布鲁氏菌感染调控中的作用及其机制,家畜疫病病原生物学国家重点实验室(兰州兽医研究所)开放基金(SKLVEB2015KFKT-0017),主持,5万元,2015-2017

  6.β-乳球蛋白基因敲除奶山羊新品种培育,农业部生物新品种培育重大专项(2014 ZX08008-004),子课题,60万,2014-2015

  7.奶山羊新品种培育,农业部生物新品种培育重大专项(2011ZX08008-004),子课题,55万元 ,2011-2013

  8.LRF介导的内质网应激在胚胎着床过程中的作用及其调节机制,国家自然科学基金(31372499),主要参加,80万元,2014-2017

六、荣誉及奖项

  2009年获校级优秀青年教师指导教师

  2012年获校级教学成果奖二等奖1项

七、个人联系方式

  通讯地址:陕西省杨凌示范区西农路22号西北农林科技大学动物医学院

  邮编:712100

  电话:13087521339

  E-mail:aihuawang1966@163.com

  


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